Jacksonville clinched a place in the AFC play-offs on Sunday when they beat Oakland 49-11, the Raiders' worst result of the season so far.
Fred Taylor's 62-yard touchdown run on the Jaguars' opening play set the tone for a commanding performance which earned their sixth win in seven games.
New York Giants ensured their play-off place with a 38-21 win over Buffalo.
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Cleveland are still struggling for a play-off spot after they went down 19-14 to Cincinnati, who have nothing left to play for this season.
Two consecutive interceptions from Derek Anderson's throwing set up the Bengals' touchdowns late in the first half, as he threw four in total in the match.
Victory in Cincinnati would have ensured the Browns a place in the play-offs.
Donovan McNabb passed for 263 yards and three touchdowns as Philadelphia upset New Orleans 38-23, damaging the home team's chances of reaching the play-offs.
Chicago thumped Green Bay 35-7 to end the Packers' chances of home field advantage in the play-offs.
Brian Urlacher returned an 85-yard interception for a touchdown and Adrian Peterson ran for 102 yards as the Bears won in snowy conditions.
Green Bay's Brett Favre passed for just nine yards in the first half but his 153 yards overall put him over the 4,000-yard mark in a season for the fifth time.
Indianapolis beat the Dallas Texans 38-15 for their sixth win in a row and Detroit ended a six-game losing streak with a 25-20 win over Kansas City.
In the weekend's opening game, Pittsburgh beat struggling St Louis 41-24 to stay top of the AFC North but at the cost of losing the league's leading running back, Willie Parker, to a broken right leg.
Parker's replacement, Najeh Davenport, rushed for 123 yards and a touchdown and also caught a touchdown pass.
(BBC)
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