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The declaration, which is six months overdue, should contain full details of its plutonium enrichment efforts.
But analysts have cautioned that it is not expected to include information about alleged attempts by Pyongyang to enrich uranium.
Correspondents say it could lead to North Korea being taken off the US list of states sponsoring terrorism.
The handover is part of six-party talks aimed at disarming North Korea, which tested a nuclear weapon in 2006.
The expected development is dominating a meeting of G8 foreign ministers in Japan.
In North Korea itself, a senior US diplomat and media have been invited to witness the destruction of a nuclear cooling tower on Friday.
(BBC)
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